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  • Prolonged Sitting Tied to Brain Atrophy The beneficial effects of physical activity on brain health are well documented, but less is known about the impact of sedentary behavior on brain structures that involve memory.

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  • ACIP Recommends Heplisav-B Vaccine for AdultsHeplisav-B, a yeast-derived hepatitis B vaccine made with a novel adjuvant, is recommended for individuals aged 18 years and older, according to the Advisory Committee on Immunization Practices.
  • Ambulatory 24-Hour BP Monitoring Best Predicts MortalityThe largest study ever conducted of ambulatory blood pressure monitoring shows 24-hour measures predict mortality much better than do office measurements and should now be routine, researchers say.
  • Timing Cortisol Therapy Could Improve Adrenal InsufficiencyGiving cortisol replacement therapy in a pattern that mimics normal rhythms of human secretion could result in better sleep quality and cognitive function compared with standard dosing, say UK researchers.
  • Glasgow Coma Scale Gets an Eye-Opening UpdateResearchers have found that adding pupil response to the scale more accurately predicts prognosis after TBI, including the likelihood of death, than either measure alone.
  • Opioid Prescriptions See Largest Annual Drop in 25 YearsFactors driving the decline in opioid prescriptions include major clinical guideline shifts, payer reimbursement controls, and regulatory and legislative restrictions; meanwhile, overall use of medications continued to rise in 2017, a new report shows.


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  • Eric J. Topol, MD Eric J. Topol, MD Director, Scripps Translational Science Institute; Executive Vice President and Professor of Molecular Medicine, The Scripps Research Institute; Senior Consultant, Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California; Editor-in-Chief, Medscape

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