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  • Delabeling for Penicllin Allergy Found Safe in ChildrenChildren with low-risk penicillin allergy symptoms who tested negative for penicillin allergy tolerated penicillin without serious adverse or allergic reactions during the following year, a study found.
  • ACIP Recommends Heplisav-B Vaccine for AdultsHeplisav-B, a yeast-derived hepatitis B vaccine made with a novel adjuvant, is recommended for individuals aged 18 years and older, according to the Advisory Committee on Immunization Practices.
  • Ambulatory 24-Hour BP Monitoring Best Predicts MortalityThe largest study ever conducted of ambulatory blood pressure monitoring shows 24-hour measures predict mortality much better than do office measurements and should now be routine, researchers say.
  • Timing Cortisol Therapy Could Improve Adrenal InsufficiencyGiving cortisol replacement therapy in a pattern that mimics normal rhythms of human secretion could result in better sleep quality and cognitive function compared with standard dosing, say UK researchers.
  • Opioid Prescriptions See Largest Annual Drop in 25 YearsFactors driving the decline in opioid prescriptions include major clinical guideline shifts, payer reimbursement controls, and regulatory and legislative restrictions; meanwhile, overall use of medications continued to rise in 2017, a new report shows.

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  • A 39-year-old woman experiences vomiting and a severe occipital headache that she describes as the worst she has ever had. She suffered a similar headache two days ago.
  • Reviews have questioned the quality of studies of stem cell therapy for knee osteoarthritis, citing high risk of bias, low quality of evidence, only modest improvement reported, and possible placebo effect.

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